The Most Notorious Cold Cases In The United States

True crime has become one of the most popular genres in media because these stories could happen to anybody. Whether it be through a Netflix docuseries, podcast, or best-selling memoir, the U.S. has seen a ton of cold cases over the years. From famous rappers to iconic actors, here are the most famous unsolved cases that left detectives scratching their heads.

No One Knows Why Edgar Allan Poe Left

Edgar Allan Poe was one of the most historic writers of all time with works still being taught in school today.

edgar allan poe black and white portrait
Matthew Brady/Getty Images
Matthew Brady/Getty Images

His passing still remains a mystery. He was found delirious on the streets of Baltimore, Maryland about four days before his passing. Some saw him wearing clothes that were not his with him shouting the name “Reynolds.”

The Women Of Ciudad Juaréz Don’t Have Justice

Sitting right at the U.S. border is a town called Juaréz. It’s usually referred to as the “City of the Lost Girls” because hundreds, or possibly thousands, of women have disappeared there over the last decade.

View of crosses representing 26 murdered women during a protest on the eve of the International Day for the Elimination of Violence Against Women in Juarez, Mexico
Herika Martinez/Getty Images
Herika Martinez/Getty Images

While Amnesty International has urged the Mexican authorities to find the perpetrators, there has been little done to stop the injustice.

What Happened To John Middleton Clayton?

This event is rarely taught in history class. When John Middleton Clayton was running for a seat in the U.S. Congress in Arkansas, the ballot box was stolen.

john middleton clayton portrait from 1843
Heritage Art/Heritage Images via Getty Images
Heritage Art/Heritage Images via Getty Images

Four masked men stole it at gunpoint and it turned out most of the votes were for Clayton. Clayton was later assassinated and declared the winner. His assassin’s identity remains unknown.

People Were Poisoned By Tylenol

One of the biggest mysteries of the 1980s were the Tylenol poisonings during September and October of 1982. Seven people in the Chicago area passed after taking Tylenol pills laced with cyanide.

Drugstore clerk removes Tylenol capsules from the shelves of a pharmacy
Yvonne Hemsey/Getty Images
Yvonne Hemsey/Getty Images

The medicine was quickly removed from shelves and no one was able to trace the location of the laced pills.

Mary Meyer Was Close To JFK

Those close to John F. Kennedy have dealt with immense tragedy. Mary Meyer was a personal friend to JFK and a Washington D.C. native.

mary meyer and jfk split image
Robert L. Knudsen/Wikimedia Commons/Bettmann/Getty Images
Robert L. Knudsen/Wikimedia Commons/Bettmann/Getty Images

Her body was found in 1964 after a man followed her and shot her while she was on a walk. A man was arrested for taking her life, but was later released because he wasn’t the man who shot her.

The Grimes Sisters Were Supposed To See A Movie

On a Chicago night in 1956, two sisters named Barbara and Patricia Grimes decided to go see a movie. They never made it to the theater and their bodies were found a year later.

William J. Willingham, Jr. holding photos of the Grimes sisters
Bettmann/Getty Images
Bettmann/Getty Images

A suspect was never declared, but the man on the right, William J. Willingham, Jr., was a supposed accomplice to the crime.

Jack The Ripper Was A Lot More Vicious Than Most Thought

Jack the Ripper may sound like a character from a children’s book, but he was a lot more vile and vicious than most probably knew.

Laird Cregar playing the role of Jack the Ripper in 1944's The Lodgere
Hulton Archive/Getty Images
Hulton Archive/Getty Images

Between August 7 and November 10 of 1888, five women had their lives taken by him. Jack the Ripper would often leave taunting notes with his victims, but his identity was never revealed.

Tupac Shakur Has Been Gone For Over 25 Years

Tupac Shakur was one of the most popular rappers and actors of the 1990s. His music is internationally acclaimed after selling more than 75 million records worldwide.

tupac shakur poses backstage for a photo in 1994
Raymond Boyd/Getty Images
Raymond Boyd/Getty Images

Shakur was involved in a drive-by shooting in Las Vegas during September of 1996 and he was gone six days later. There is no sufficient evidence that has led to any arrests.

There Are No Suspects In The Case Of The Notorious B.I.G.

Christopher George Latore Wallace went by several stage names including The Notorious B.I.G., Biggie, and Biggie Smalls. He was one of the most influential hip hop artists in the 1990s, especially on the East Coast.

notorious big at the billboard music awards in 1995
Larry Busacca/WireImage/Getty Images
Larry Busacca/WireImage/Getty Images

Wallace was the victim of a drive-by shooting in Los Angeles in March of 1997 and no one was named a suspect.

The Black Dahlia Was A 1940s Mystery

One of the biggest cold cases of the 1940s was the case of The Black Dahlia. A woman named Elizabeth Short was working as a waitress in Hollywood with a dream of becoming a famous actress.

black and white photo of elizabeth short
Bettmann/Getty Images
Bettmann/Getty Images

She went missing on January 9, 1947, and was found unresponsive in a residential part of Los Angeles. After almost 75 years, no one has been arrested for the crime.

O.J. Simpson’s Glove Didn’t Fit

Millions of people watched the O.J. Simpson trial in the mid-1990s when he was accused of ending the life of his ex-wife Nicole Brown and her partner Ron Goldman.

oj simpson in court in 1994
POOL/AFP via Getty Images
POOL/AFP via Getty Images

Simpson was acquitted by the jurors when he convinced them that the gloves of the killer didn’t fit. He was later found liable in a civil suit, but the criminal case is still unsolved.

There Were Many Suspects With The William Desmond Taylor Case

One of the biggest cold cases of the 1920s was the case of silent film director William Desmond Taylor. He was found shot in the back in his home on February 2, 1922.

william desmond taylor black and white portrait
Bettmann/Getty Images
Bettmann/Getty Images

There are many suspects to the case including a young actress who had unrequited love for him, a shady valet driver, and a jealous boyfriend.

Jimmy Hoffa’s Body Has Never Been Found

Jimmy Hoffa may look familiar because he was a former labor union president and a famous gangster. He was last seen in Bloomfield Township, Michigan in 1975 in the parking lot of a restaurant.

jimmy hoffa in 1966
Bettmann/Getty Images
Bettmann/Getty Images

Experts revealed he was waiting to meet someone, but Hoffa was never seen after that. His body has never been found after almost five decades.

Game Show Host’s Case Remains Unsolved

Not only was Dorothy Kilgallen a game show host, but she was also a columnist and journalist. She started working for the New York Evening Journal at 17-years-old.

dorothy kilgallen wearing a hat and gloves
Bettmann Archive/Getty Images
Bettmann Archive/Getty Images

Kilgallen’s body was found in her Manhattan townhouse on November 8, 1965. While some think it was because she was intoxicated, there are suspicions that someone took her life by needle injection.

Thelma Todd Found Inside A Garage

Thelma Todd was an actress in the 1920s and 1930s known for roles in The Maltese Falcon, The Bohemian Girl, Monkey Business, and more.

thelma todd in the maltese falcon
Donaldson Collection/Getty Images
Donaldson Collection/Getty Images

On the morning of December 16, 1935, Todd was found inside the garage of the ex-wife of her current partner Roland West. While her passing was caused by carbon monoxide poisoning, it was never determined if she or someone else ended her life.

TV Actress Barbara Colby Was Shot For No Reason

Barbara Columbo was a relatively unknown TV actress who had guest roles on shows such as Columbo, The Odd Couple, and The Mary Tyler Moore Show.

barbara colby on Columbo
Universal Television
Universal Television

On July 24, 1975, she and fellow actor, James Kiernan, were walking to their cars after an acting class in Los Angeles. Both were shot by two men they did not recognize and there was no motive that detectives could figure out.